Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 162, Issue -, Pages 385-393Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.06.148
Keywords
Ovomucin; Hydrolyticpeptide; Bioactivity; Intestinalhealth; Sialicacid
Funding
- China Postdoctoral Science Foundation [2019M663834]
- National Key Research and Development Program of China [2018YFD0400303]
- National Natural Science Foundation of China [31501506]
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Intestinal dysfunction, which may cause a series of metabolic diseases, has become a worldwide health problem. In the past few years, studies have shown that consumption of poultry eggs has the potential to prevent a variety of metabolic diseases, and increasing attention has been directed to the bioactive proteins and their peptides in poultry eggs. This review mainly focused on the biological activities of an important egg-derived protein named ovomucin. Ovomucin and its derivatives have good anti-inflammatory, antioxidant, immunity-regulating and other biological functions. These activities may affect the physical, biological and immune barriers associated with intestinal health. This paper reviewed the structure and the structure-activity relationship of ovomucin, the potential role of ovomucin and its derivatives in modulation of intestinal health are also summarized. Finally, the potential applications of ovomucin and its peptides as functional food components to prevent and assist in the pretreatment of intestinal health problems are prospected. (c) 2020 Elsevier B.V. All rights reserved.
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