Journal
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
Volume 35, Issue 10, Pages 2148-2155Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ja00180e
Keywords
-
Categories
Funding
- Inter-institutional Collaborative Research Scheme, Hong Kong Baptist University [RC-ICRS/16-17/02B]
- Inter-disciplinary Research Matching Scheme, Hong Kong Baptist University [RC-IRMS/16-17/01A]
- Science, Technology and Innovation Commission of Shenzhen [JCYJ20170817173243420]
- University Grants Committee
Ask authors/readers for more resources
Single particle inductively coupled plasma-mass spectrometry (sp-ICP-MS) is becoming a popular tool to analyze nanoparticles. However, the complicated matrices of NPs hamper their accurate mass quantification and size characterization. Worse still, the NPs in real samples are likely to be polydisperse, which makes them even harder to analyze. Here, CeO(2)NPs, a typical kind of NPs with a broad size distribution, were used to study the matrix effect on sp-ICP-MS analysis in three types of biological samples, namely enzyme-digested matrix, urine and plasma. The matrix effect on sp-ICP-MS was addressed by comparing mass concentrations determined by sp-ICP-MS and ICP-MS. We then applied internal standardization to correct for the matrix effect in sp-ICP-MS analysis. Through these experiments, we demonstrated that internal standardization is effective and practical in correcting for the matrix effect of multiple NPs in real samples at different dilution levels.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available