Journal
SCIENCE ADVANCES
Volume 6, Issue 45, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aaz8934
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Funding
- DFG [BR 5951/1-1, SFB 1158, TRR 265, ME 1591/4-1]
- German Research Foundation (DFG) [SFB 1158, TRR 265, GRK 2350, TO 539/3-1]
- German Federal Ministry of Education and Research (BMBF) [01EF1803A, 01GQ1102]
- European Union's Seventh Framework Programme [602450, 602805, 115300, HEALTH-F2-2010-241909]
- Innovative Medicines Initiative Joint Undertaking (IMI) [115008]
- Ministry of Science, Research and the Arts of the State of Baden-Wuerttemberg, Germany [MWK] [42-04HV. MED(16)/16/1]
- BMBF [01EF1803A, 01ZX1314G, 01GQ1003B]
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Physical activity substantially improves well-being and mental health, but the underlying brain processes remain unclear. Most research concerns exercise, although the majority of everyday human behaviors, such as walking or stair climbing, are nonexercise activities. Combining neuroimaging with ecological assessment of activity and GPS-triggered smartphone diaries, we show a specific association of nonexercise activity with energy in two independent samples mediated by the subgenual part of the anterior cingulate cortex (sgACC), a key emotion regulatory site. Furthermore, energy predicted a range of mental health metrics. sgACC volume moderated humans' emotional gain from nonexercise activity in real life: Individuals with low sgACC volume, a risk factor for depression, felt less energized when inactive but benefited more from periods of high nonexercise activity. This suggests an everyday life mechanism affecting affective well-being in the general population and, if substantiated in patient samples, a risk and resilience process for mood disorders.
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