Journal
PATHOGENS
Volume 9, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/pathogens9110925
Keywords
influenza A virus; RNA structure; replication; antiviral strategies; RNA interference; antisense oligonucleotides; catalytic nucleic acids
Categories
Funding
- National Science Center [UMO-2019/35/D/NZ6/01479, UMO-2020/01/0/NZ6/00137, UMO-2019/33/B/ST4/01422, UMO-2017/25/B/NZ1/02269]
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Influenza is an important research subject around the world because of its threat to humanity. Influenza A virus (IAV) causes seasonal epidemics and sporadic, but dangerous pandemics. A rapid antigen changes and recombination of the viral RNA genome contribute to the reduced effectiveness of vaccination and anti-influenza drugs. Hence, there is a necessity to develop new antiviral drugs and strategies to limit the influenza spread. IAV is a single-stranded negative sense RNA virus with a genome (viral RNA-vRNA) consisting of eight segments. Segments within influenza virion are assembled into viral ribonucleoprotein (vRNP) complexes that are independent transcription-replication units. Each step in the influenza life cycle is regulated by the RNA and is dependent on its interplay and dynamics. Therefore, viral RNA can be a proper target to design novel therapeutics. Here, we briefly described examples of anti-influenza strategies based on the antisense oligonucleotide (ASO), small interfering RNA (siRNA), microRNA (miRNA) and catalytic nucleic acids. In particular we focused on the vRNA structure-function relationship as well as presented the advantages of using secondary structure information in predicting therapeutic targets and the potential future of this field.
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