Journal
CARBOHYDRATE POLYMERS
Volume 247, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116728
Keywords
Leukopenia; Sulfated polymannuroguluronate; TGC161; CD4(+)T cell apoptosis; Chemotherapy
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Funding
- National Natural Science Foundation of China [31700755, 81991525]
- Taishan Scholars Program [tsqn201909170]
- Fundamental Research Funds for the Central Universities
- Innovative Leader of Qingdao Program [19-3-2-26-zhc]
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Polysaccharides have aroused considerable interest due to their diverse biological activities and low toxicity. In this study, we evaluated the effect of marine polysaccharide sulfated polymannuroguluronate (TGC161) on the leukopenia induced by chemotherapy. It is found that TGC161 ameliorates the leukopenia. Besides, TGC161 would promote CD4(+) T cell differentiation and maturation in the thymus, but does not have a significant effect on precursor cells in bone marrow. Furthermore, TGC161 inhibits CD4(+) T cell apoptosis in vitro. Collectively, our findings offer a natural and harmless polysaccharide to ameliorate leukopenia.
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