Journal
CHEMOSPHERE
Volume 259, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2020.127380
Keywords
Fomesafen; Zebrafish; Oxidative stress; Cell apoptosis; Developmental toxicity
Categories
Funding
- National Natural Science Foundation of China [31771606]
- China Postdoctoral Foundation [2019M652269]
- Natural Science Foundation Project of Jiangxi Province [2018ACB21033]
- Postdoctoral Science Foundation of Jiangxi Province [2018RC15, 2019KY20]
Ask authors/readers for more resources
Fomesafen is widely used in agriculture and can be detected in the environment and agricultural products. Research on the developmental toxicity of fomesafen in animals is currently very limited. Here, we used zebrafish as an animal model to evaluate the toxicity of fomesafen in developing aquatic vertebrates and higher animals. From 6h to 72h following fertilization, exposure of zebrafish embryos to 5, 10 and 20 mg/L of fomesafen resulted in pericardial edema, a reduction in heart rate, shortening of body length, and yolk sac edema. Fomesafen reduced the number of immune cells such as neutrophils and macrophages, increased the expression of a number of inflammatory factors, induced the up-regulation of the oxidative stress response and apoptosis, and disrupted the activity of enzymes related to nerve development, which affected the motility of the embryos. In conclusion, the results provide new evidence for the comprehensive assessment of fomesafen toxicity in aquatic vertebrates. (C) 2020 Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available