Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 7, Issue 20, Pages 3247-3252Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo00789g
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21772038, 21971062]
- Research Center of Analysis and Test of East China University of Science and Technology
Ask authors/readers for more resources
A highly efficient kinetic resolution of racemic 2H-azirines has been achieved by catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides. With an (S,S-p)-Ph-Phosferrox/Cu(MeCN)(4)BF(4)complex as the catalyst, optically pure 2H-azirines were obtained with excellent enantioselectivities (up to 99% ee) and high resolution efficiency (Sfactors up to 845). Meanwhile, this process provided a direct approach to synthesize structurally novel 1,3-diazabicyclo[3.1.0]hexane derivatives with excellent enantioselectivities (94-99% ee).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available