Novel carbohydrate-triazole derivatives as potential α-glucosidase inhibitors

A series of novel pyrano[2, 3-d]trizaole compounds were synthesized and their alpha-glucosidase inhibitory activities were evaluated by in vitro enzyme assay. The experimental data demonstrated that compound 10f showed up to 10-fold higher inhibition (IC50 74.0 +/- 1.3 mu mol.L-1) than acarbose. The molecular docking revealed that compound 10f could bind to alpha-glucosidase via the hydrophobic, pi-pi stacking, and hydrogen bonding interactions. The results may benefit further structural modifications to find new and potent a-glucosidase inhibitors.