Journal
NON-CODING RNA
Volume 6, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ncrna6030026
Keywords
lncRNA; NEAT1; paraspeckle; DNA damage repair; cancer; neurodegenerative disease
Funding
- Associazione Italiana Ricerca sul Cancro (AIRC) [IG16722, IG10136, 9980]
- AIRC [IG21588]
- Italian Ministry of Health [GR-2016-02361523]
- Fondazione Italiana Ricerca sul cancro (FIRC) [19370]
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Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.
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