Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 40, Pages 8141-8146Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01824d
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Funding
- National Natural Science Foundation of China [21772236]
- School of Pharmaceutical Sciences (South-Central University for Nationalities)
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A simple and efficient synthetic protocol for the preparation of acridinium esters and amides through the cyclization and esterification or amidation of isatins with alcohols or amines as nucleophiles in the presence of CF3SO3H is established. A series of polycyclic acridine derivatives bearing large pi-conjugated systems were obtained in high yields, including some key intermediates for the synthesis of biologically active molecules. The photophysical properties of these synthesized acridines were investigated, demonstrating that the sulfur heterocyclic acridine9wwas obtained in a high quantum yield.
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