Journal
CYTOMETRY PART A
Volume 97, Issue 12, Pages 1217-1221Publisher
WILEY
DOI: 10.1002/cyto.a.24249
Keywords
COVID-19; sepsis; HLA-DR; flow cytometry
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Funding
- Claude Bernard Lyon I University
- Hospices Civils de Lyon
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Several months after the sudden emergence of SARS-CoV-2 and COVID-19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition, COVID-19 falls in the scope of septic syndromes (organ dysfunction due to dysregulated host response to an infection) in which immunosuppression is a significant driver of mortality. Sepsis-induced immunosuppression is mostly defined and monitored by the measurement of decreased expression of HLA-DR molecules on circulating monocytes (mHLA-DR). In this interim review, we summarize the first mHLA-DR results in COVID-19 patients. In critically ill patients, results homogenously indicate a decreased mHLA-DR expression, which, along with profound lymphopenia and other functional alterations, is indicative of a status of immunosuppression. (c) 2020 International Society for Advancement of Cytometry
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