Journal
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
Volume 13, Issue -, Pages -Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1756284820942616
Keywords
alcohol-related liver disease; bacterial translocation; cirrhosis; gut barrier; intestinal permeability
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Funding
- Imperial Biomedical Research Centre
- MRC Precision Medicine grant Minimising Mortality in Alcoholic Hepatitis
- MRC [MR/R014019/1] Funding Source: UKRI
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Increased bacterial translocation (BT) across the gut barrier due to greater intestinal permeability (IP) is seen across a range of conditions, including alcohol-related liver disease (ArLD). The phenomenon of BT may contribute to both the pathogenesis and the development of complications in ArLD. There are a number of methods available to assess IP and in this review we look at their various advantages and limitations. The knowledge around BT and IP in ArLD is also reviewed, as well as the therapeutic strategies currently in use and in development.
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