Journal
HELIYON
Volume 6, Issue 9, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2020.e05031
Keywords
Biochemistry; Oxidative stress; Biomolecules; Aging; Biomarkers; Polyamine; Ornithine decarboxylase; Adenosylmethionine decarboxylase; Spermine oxidase; Acrolein-conjugated lysine
Categories
Funding
- Japan Society for the Promotion of Science [17K09270]
- Grants-in-Aid for Scientific Research [17K09270] Funding Source: KAKEN
Ask authors/readers for more resources
The polyamines spermidine, spermine and putrescine are essential for normal cellular functions. The contents of polyamines in tissue decreased in aged mice compared to young mice. In this study, the polyamine contents and their metabolic byproduct acrolein-conjugated lysine (N-epsilon-(3-formyl-3,4-dehydropiperidino)-lysine, FDP-Lys) in human liver tissue were measured and analyzed the correlation with age of the subjects. The putrescine and FDP-Lys levels were significantly increased with age. On the other hand, spermine level was decreased with age. Spermidine did not significantly correlate with age. The relative amount of spermine oxidase (SMOX) significantly correlated with the age of subjects whereas ornithine decarboxylase (ODC) and adenosylmethionine decarboxylase (AMD1) significantly reduced by the age. Our results suggested that an increase in oxidation and reduction in polyamine synthesis may cause the change of polyamine profile in the elderly.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available