Journal
TETRAHEDRON
Volume 76, Issue 45, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2020.131571
Keywords
C-alklation; Alcohols; Transition metal free
Categories
Funding
- School of Chemistry, Cardiff University
- Tertiary Education Trust Fund (TETFund)
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A base-mediated alpha-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols to be employed as alkylating agents. Aryl methyl ketones undergo selective mono-alpha-C-alkylation in high isolated yields (23 examples, 65% average yield). (C) 2020 Elsevier Ltd. All rights reserved.
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