Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 195, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111263
Keywords
Nanoparticles; Wound healing; Curcumin; Cerium oxide; Antioxidant; Amphiphilic
Funding
- Ministry of Human Resource Development (MHRD)
- Indian Council of Medical Research (ICMR) [IMPRINT-6714]
- Department of Science and Technology (DST), Ministry of Science and Technology [DST/INT/SWD/P-11/2016, DST/NM/NT-2018/48]
- ICMR
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During injury or diseased condition, wound dressing fails to properly integrate or repair the tissue and restore its function due to various factors like poor bioavailability, systemic delivery of hydrophobic drugs and elevated levels of reactive oxygen species. Here, we fabricated a novel nano-hybrid hydrogel system, based-on gelatin and oxidized dextran, embedded with nano-formulation of curcumin and cerium oxide, dispersed by physical interaction within the hydrogel. The curcumin was entrapped in amphiphilic alkylated-dextran nanoparticles to enhance its bioavailability and release at the injured site while cerium oxide nanoparticles were used without any additional processing. The hydrogel was characterized for various properties and demonstrated a controlled and prolonged drug release (similar to 63 % in 108 h), accelerated cell migration besides providing a highly significant antioxidant and in-vivo anti-inflammatory activity (similar to 39 %). The preliminary study suggests that this hybrid system can significantly promote wound healing and the potential to become an ideal wound dressing.
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