Journal
ANALYST
Volume 145, Issue 21, Pages 7009-7017Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0an01247e
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [U1704153]
- 1000 Talents Program of Zhongyuan
- Plan for Young Excellent Teachers in Universities of Henan Province [2017GGJS100]
- Nanhu Scholars Program for Young Scholars of XYNU
Ask authors/readers for more resources
As a class of ideal fluorescent nanomaterials, self-assembled copper nanoclusters (CuNCs) have attracted increasing interest. Unfortunately, most of these CuNCs only possessed bright luminescence in acidic solution, which limited their practical applications in a physiological environment. Retaining the strong fluorescence of these CuNCs in neutral or alkaline solution is still a challenging task. In this strategy, self-assembled CuNCs were prepared by using 4-methylthiophenol as the protecting ligand. The self-assembled CuNCs display stable and bright luminescence with excitation/emission maxima at 330/605 nm even in neutral and alkaline environments. Interestingly, with the addition of glutathione (GSH), the fluorescence intensity of CuNCs is enhanced strongly through the GSH-controlled aggregation-induced emission enhancement of self-assembled CuNCs. The turn-on fluorescence strategy can determine the GSH concentration in the range from 1 to 100 mu M with a limit of detection of 300 nM. In addition, the method is employed for the determination of GSH levels in cells. Therefore, the turn-on fluorescence strategy is reliable, sensitive and suitable for the determination of cellular GSH levels.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available