Journal
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
Volume 494, Issue 1, Pages 244-247Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1607672920050075
Keywords
BDNF; NGF; dipeptide mimetics; PI3K; AKT; MAPK; ERK; PLC-γ 1
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Previously, we designed and synthesized dipeptide mimetics of individual loops of the nerve growth factor (NGF) and the brain-derived neurotrophic factor (BDNF). It was shown that these mimetics activate the corresponding tyrosine kinase (Trk) receptors and have different patterns of activation of the PI3K/AKT and MAPK/ERK postreceptor signaling pathways in vitro. In the present study, it was shown on HT-22 cells that all these compounds activate the phospholipase C-gamma 1 (PLC-gamma 1) cascade.
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