Journal
JOURNAL OF TRANSLATIONAL MEDICINE
Volume 18, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12967-020-02609-0
Keywords
Autoimmunity; Biomarker; Therapy; Extracellular vesicle; Exosomes; MicroRNA
Categories
Funding
- National Natural Scientific Foundation of China [81870767, 81570978]
- Project of Jiangsu Provincial Medical Youth Talent [QNRC2016118]
- Key Project of the Science and Technology Department of Jiangsu Province [BL2014018]
- Nanjing Medical Science and Technique Development Foundation [ZKX17033]
- Talent Foundation Project of Nanjing Stomatological Hospital, Medical School of Nanjing University [21]
- Nanjing Clinical Research Center for Oral Diseases [2019060009]
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Extracellular vesicles are heterogeneous populations of naturally occurring secreted small vesicles. EVs function as signaling platforms to facilitate intracellular communication, which indicates the physiological or pathophysiological conditions of cells or tissues. Considering that EVs can be isolated from most body fluids and that molecular constituents could be reprogrammed according to the physiological status of the secreting cells, EVs are regarded as novel diagnostic and prognostic biomarkers for many diseases. The ability to protect encapsulated molecules from degradation in body fluids suggests the potential of EVs as biological medicines or drug delivery systems. This article focuses on the EV-associated biomarkers and therapeutic approaches in autoimmune diseases.
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