Journal
ANTIVIRAL RESEARCH
Volume 183, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.antiviral.2020.104937
Keywords
PRRSV; IL-10; STAT3; CD163; Cryptotanshinone; PAM
Categories
Funding
- Agriculture and Food Research Initiative Competitive from the USDA/National Institute of Food and Agriculture (NIFA) [2017-67016-26675]
Ask authors/readers for more resources
Porcine reproductive and respiratory syndrome (PRRS), caused by PRRS virus (PRRSV) infection, imposes enormous economic impact to the world pork industry. Currently there is no effective treatment to prevent PRRSV infection in swine. We report that the natural compound cryptotanshinone (Cpt) effectively inhibits the infection of various strains of PRRSV to porcine alveolar macrophages (PAMs), the primary cell target of PRRSV in vivo. Mechanistically, Cpt inhibits the activation of signal transducer and activator of transcription 3 (STAT3), and blocks the interleukin 10 (IL-10) stimulated as well as the basal level CD163 expression in PAMs. Cpttreatment of PAMs is effective when applied either before or after PRRSV infection, with the combined preand post-PRRSV infection treatment resulting in the most significant, dose-dependent inhibition of PRRSV infection. Cpt inhibited both type I/II PRRSV infection in PAMs. Our study identified a new approach to prevent/treat PRRSV infection of pigs with natural compounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available