Journal
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
Volume 14, Issue 2, Pages 345-352Publisher
IEEE COMPUTER SOC
DOI: 10.1109/TCBB.2015.2407393
Keywords
Protein-protein interaction network; PPIs assessment; geometric embedding
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Funding
- National Science Foundation of China [61133010, 61373105, 61520106006, 31571364, 61303111, 61411140249, 61402334, 61472282, 61472280, 61472173, 61572364, 61272333]
- China Postdoctoral Science Foundation Grant [2014M561513]
- National High-Tech RD Program (863) [2014AA021502, 2015AA020101]
- Ph.D. Programs Foundation of Ministry of Education of China [20120072110040]
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In recent years, a remarkable amount of protein-protein interaction (PPI) data are being available owing to the advance made in experimental high-throughput technologies. However, the experimentally detected PPI data usually contain a large amount of spurious links, which could contaminate the analysis of the biological significance of protein links and lead to incorrect biological discoveries, thereby posing new challenges to both computational and biological scientists. In this paper, we develop a new embedding algorithm called local similarity preserving embedding (LSPE) to rank the interaction possibility of protein links. By going beyond limitations of current geometric embedding methods for network denoising and emphasizing the local information of PPI networks, LSPE can avoid the unstableness of previous methods. We demonstrate experimental results on benchmark PPI networks and show that LSPE was the overall leader, outperforming the state-of-the-art methods in topological false links elimination problems.
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