Journal
DRUG DISCOVERIES AND THERAPEUTICS
Volume 14, Issue 5, Pages 232-238Publisher
INT RESEARCH & COOPERATION ASSOC BIO & SOCIO-SCIENCES ADVANCEMENT
DOI: 10.5582/ddt.2020.03078
Keywords
gestational diabetes mellitus; depressive symptom; nutrition
Categories
Funding
- JSPS KAKENHI [JP25670970, JP17K17492]
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The objective of this study was to explore the factors associated symptoms of depression among pregnant women with gestational diabetes mellitus (GDM) in Japan. This cross-sectional study was conducted at a hospital in Toyota, Japan, from January 2015 to June 2016. Pregnant women who visited the hospital and were diagnosed with GDM in the second trimester were enrolled. We analyzed depression symptoms using the Centers for Epidemiological Studies Depression Scale (CES-D) and considered related factors of depression symptoms, such as dietary intake and daily walking. Dietary intake during the past month was assessed using a brief self-administered diet history questionnaire, and daily walking was assessed using an accelerometer. The prevalence rate for GDM was 8.8%, and 25 pregnant women with GDM were analyzed. The CES-D was not significantly correlated with pre-pregnancy BMI, postprandial plasma glucose, hemoglobin A1c, and the number of steps walked. In contrast, a significant negative correlation was observed between the CES-D score and intake of fish with bones, simmered fish, pickles, green leaves, mushrooms, and green tea. Furthermore, a significant positive correlation was found between Coke (R) and CES-D scores. For nutrient intake, a significant negative correlation was found between the CES-D score and vitamin K, folate, and beta-carotene levels. The present study suggests that depression symptoms among pregnant women with GDM in the second trimester may be associated with diet.
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