Journal
FOOD SCIENCE & NUTRITION
Volume 8, Issue 12, Pages 6513-6527Publisher
WILEY
DOI: 10.1002/fsn3.1941
Keywords
dietary obesity; gut microbiota; novel high-DHA tuna oil
Categories
Funding
- open fund of state key laboratory for managing biotic and chemical threats to the quality and safety of agro-products and regional demonstration project of marine economic innovation and development in 2014
- K. C. Wong Magna Fund in Ningbo University
- open fund of state key laboratory for managing biotic and chemical threats to the quality and safety of agro-products and regional demonstration project of marine economic innovation and development in 2016
Ask authors/readers for more resources
Studies have documented the benefits of fish oil in different diseases because of its high n-3 polyunsaturated fatty acid content. However, these studies mostly used commercially available fish oil supplements with a ratio of 18/12 for eicosapentaenoic acid and docosahexaenoic acid (DHA). However, increasing DHA content for this commonly used ratio might bring out a varied metabolic effect, which have remained unclear. Thus, in this study, a novel tuna oil (TO) was applied to investigate the effect of high-DHA content on the alteration of the gut microbiota and obesity in high-fat diet mice. The results suggest that high-DHA TO (HDTO) supplementation notably ameliorates obesity and related lipid parameters and restores the expression of lipid metabolism-related genes. The benefits of TOs were derived from their modification of the gut microbiota composition and structure in mice. A high-fat diet triggered an increased Firmicutes/Bacteroidetes ratio that was remarkably restored by TOs. The number of obesity-promoting bacteria-Desulfovibrio, Paraeggerthella,Terrisporobacter, Millionella, Lachnoclostridium, Anaerobacterium, and Ruminiclostridium-was dramatically reduced. Desulfovibrio desulfuricans, Alistipes putredinis, and Millionella massiliensis, three dysbiosis-related species, were especially regulated by HDTO. Regarding the prevention of obesity, HDTO outperforms the normal TO. Intriguingly, HDTO feeding to HFD-fed mice might alter the arginine and proline metabolism of intestinal microbiota.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available