Journal
ORGANIC LETTERS
Volume 22, Issue 22, Pages 8894-8898Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03285
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Funding
- National Natural Science Foundation of China [NSFC 21672170]
- Natural Science Basic Research Plan in Shaanxi Province of China [2018JC-020]
- China Postdoctoral Science Foundation [2018M643705]
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Asymmetric synthesis of quinoline-naphthalene atropisomers with fully blocked ortho positions has been developed by a two-step strategy, which contains a chiral phosphoric acid-catalyzed Povarov reaction and a DDQ oxidation reaction. This method provides facile access to diverse functionalized quinoline-naphthalene atropisomers with one or two chiral axes in excellent yields (<= 98%) and excellent enantioselectivities (<= 99% ee).
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