Journal
MOLECULAR MEDICINE
Volume 26, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1186/s10020-020-00234-7
Keywords
Gut microbiota; miRNA; Host pathophysiology
Funding
- National Natural Science Foundation of China [81672433, 81970551, 81970726, 81472232]
- Fundamental Research Funds for the Central Universities [PT2001]
- Henan Provincial Natural Science Foundation [182300410323]
- Program for Science & Technology Innovation Talents in Universities of Henan Province (HASTIT) [13HASTIT024]
- Plan for Scientific Innovation Talent of Henan Province
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The gut microbiota regulates the biological processes of organisms acting like 'another' genome, affecting the health and disease of the host. MicroRNAs, as important physiological regulators, have been found to be involved in health and disease. Recently, the gut microbiota has been reported to affect host health by regulating host miRNAs. For example, Fusobacterium nucleatum could aggravate chemoresistance of colorectal cancer by decreasing the expression of miR-18a* and miR-4802. What's more, miRNAs can shape the gut microbiota composition, ultimately affecting the host's physiology and disease. miR-515-5p and miR-1226-5p could promote the growth of Fusobacterium nucleatum (Fn) and Escherichia coli (E.coli), which have been reported to drive colorectal cancer. Here, we will review current findings of the interactions between the gut microbiota and microRNAs and discuss how the gut microbiota-microRNA interactions affect host pathophysiology including intestinal, neurological, cardiovascular, and immune health and diseases.
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