Journal
SCIENCE ADVANCES
Volume 6, Issue 45, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abd2068
Keywords
-
Categories
Funding
- PHS grants [R01 NS095654, R21 NS089340, P50 MH106934, RO1 MH110926, UO1 MH116488]
- Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship for Research Abroad
- Kanae Foundation
- la Caixa Foundation [100010434, LCF/BQ/PI19/11690010]
Ask authors/readers for more resources
How the rich variety of neurons in the nervous system arises from neural stem cells is not well understood. Using single-cell RNA-sequencing and in vivo confirmation, we uncover previously unrecognized neural stem and progenitor cell diversity within the fetal mouse and human neocortex, including multiple types of radial glia and intermediate progenitors. We also observed that transcriptional priming underlies the diversification of a subset of ventricular radial glial cells in both species; genetic fate mapping confirms that the primed radial glial cells generate specific types of basal progenitors and neurons. The different precursor lineages therefore diversify streams of cell production in the developing murine and human neocortex. These data show that transcriptional priming is likely a conserved mechanism of mammalian neural precursor lineage specialization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available