Journal
SCIENTIFIC REPORTS
Volume 10, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-020-75302-3
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Funding
- Kinoshita Memorial Foundation
- Suzuken Memorial Foundation
- Asahi Glass Foundation
- Takeda Science Foundation
- Naito Foundation
- Hirao Taro Foundation of KONAN GAKUEN for Academic Research
- AMED Mechano Biology [20gm5810024h0004]
- JSPS KAKENHI [18H02484, 20H05074, 18K06344, 19J40017, 19J10052]
- KAKENHI from MEXT Japan [15H05928]
- Cosmetology Research Foundation
- Hyogo Science and Technology Association
- Grants-in-Aid for Scientific Research [19J40017, 19J10052, 20H05074, 18K06344, 18H02484] Funding Source: KAKEN
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Caenorhabditis elegans (C. elegans) exhibits cold tolerance and temperature acclimatisation regulated by a small number of head sensory neurons, such as the ADL temperature-sensing neurons that express three transient receptor potential vanilloid (TRPV) channel subunits, OSM-9, OCR-2, and OCR-1. Here, we show that an OSM-9/OCR-2 regulates temperature acclimatisation and acts as an accessorial warmth-sensing receptor in ADL neurons. Caenorhabditis elegans TRPV channel mutants showed abnormal temperature acclimatisation. Ectopic expression of OSM-9 and OCR-2 in non-warming-responsive gustatory neurons in C. elegans and Xenopus oocytes revealed that OSM-9 and OCR-2 cooperatively responded to warming; however, neither TRPV subunit alone was responsive to warming. A warming-induced OSM-9/OCR-2-mediated current was detectable in Xenopus oocytes, yet ADL in osm-9 ocr-2 double mutant responds to warming; therefore, an OSM-9/OCR-2 TRPV channel and as yet unidentified temperature receptor might coordinate transmission of temperature signalling in ADL temperature-sensing neurons. This study demonstrates direct sensation of warming by TRPV channels in C. elegans.
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