Journal
NANOSCALE ADVANCES
Volume 2, Issue 11, Pages 5192-5200Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0na00549e
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Funding
- Joachim-Herz-Foundation
- German Science Foundation (DFG) via the Research Group 'Infecto-Physics'
- German Science Foundation (DFG) via Priority Program 'ESSENCE' (Schwerpunktprogramm SPP-1857)
- Federal Ministry for Research (BMBF) within the 'Forschungslabor Mikroelektronik Deutschland, ForLab' via the HELIOS-group
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Directed guidance of neurites is a pre-requisite for tailor-made designs of interfaces between cells and semiconducting components. Grayscale lithography, reactive ion etching, and ultraviolet nanoimprint lithography are potent semiconductor industry-compatible techniques for a cost- and time-effective fabrication of modulated surfaces. In this work, neurite outgrowth of murine cerebellar neurons on 2.5D pathways produced with these methods is studied. Structures of micron-sized steps and grooves serve as cell culture platforms. The effects of contact guidance through topography and chemical guidance through selective poly-D-lysine coating on these platforms are analyzed. As a consequence, the herein presented fabrication approach can be utilized to cultivate and to study low-density neuronal networks in 2.5D configuration with a high degree of order.
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