Journal
NANOSCALE
Volume 12, Issue 43, Pages 22173-22184Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr05386d
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Funding
- National Natural Science Foundation of China [51772074, U1732127, U1332117]
- Youth Top-notch Talents of Education Department of Hebei Province [BJ2017002]
- Natural Science Foundation of Hebei Province [C2020201025]
- Advanced Talents Incubation Program of Hebei University [521000981076]
- Undergraduate Innovation and Entrepreneurship Training Program of Hebei University [2020051]
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Metastasis is the main cause of treatment failure in breast cancer, and integrated phototheranostics is a promising strategy to achieve both precision theranostics and metastasis inhibition. In this work, a multifunctional phototheranostic nanoprobe composed of chlorin e6 (Ce6)-conjugated and polydopamine (PDA)-coated gold nanostars (AuNSs) was synthesized for simultaneous photoacoustic (PA) imaging, photothermal therapy (PTT) and photodynamic therapy (PDT). Under the irradiation of near infrared laser, AuNSs@PDA showed enhanced photothermal conversion and amplified PA imaging performance, compared with single AuNSs. By the covalent conjugation of Ce6, the AuNSs@PDA-Ce6 nanoprobe showed robust stability and excellent singlet oxygen (O-1(2)) generation ability. Under the combination of PTT/PDT, the AuNSs@PDA-Ce6 nanoprobes significantly reduced the growth of 4T1 tumors and suppressed their lung metastasis. All the results demonstrated the considerable potential of AuNSs@PDA-Ce6 phototheranostic nanoprobes for precision theranostics and metastasis inhibition of breast cancer.
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