Journal
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Volume 17, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/ijerph17218129
Keywords
dual-task; dementia; mild cognitive impairment; subjective cognitive impairment; gait
Funding
- Swedish Research Council [VR 2017-01259]
- Uppsala-Orebro Regional Research Council [RFR 480501, 557701, 651001]
- County Council of Uppsala [LUL431921]
- Alzheimer Foundation Sweden [AF-549011, 647881]
- Swedish Society of Medicine [SLS-594501]
- Promobilia Foundation [2016-H1, 2017-H2, 2018-H1]
- Commemorative Foundation of Ragnhild and Einar Lundstrom [LA2015-0236, 2016-0196]
- Swedish Research Council [2017-01259] Funding Source: Swedish Research Council
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The aim of this study was to investigate whether Timed Up-and-Go (TUG) dual-task (TUGdt) tests predict dementia incidence among patients with subjective or mild cognitive impairment (SCI; MCI). Other study objectives were to determine whether TUGdt improves dementia prediction compared to a) demographic characteristics and standard cognitive tests alone; and b) TUG and Verbal Fluency performed separately. Patients (n = 172, age range 39-91 years, 78 women) with SCI or MCI performed TUGdt tests, including 1) naming animals and 2) reciting months backwards, and clinical cognitive tests at baseline. Diagnoses were identified at follow-up after 2.5 years. Logistic regression was used to predict dementia incidence, receiver operating characteristic (ROC) curves and c-statistics for predictive capacity. Analyses were stratified by age and gender. At follow-up, 51 patients had developed dementia. The TUGdt result animals/10 s was associated with dementia incidence (standardized odds ratio (OR) = 4.06, 95% confidence interval (CI) 2.28-7.23, p < 0.001), more so among patients under the median age of 72 years (standardized OR = 19.4, 95% CI 3.53-106.17, p < 0.001). TUGdt animals/10 s improved dementia prediction compared to demographic characteristics and standard tests alone (c-statistics 0.88 to 0.94) and single-task tests (c-statistics 0.86 to 0.89), but only in the younger patient group. TUGdt has the potential to become a useful tool for dementia prediction.
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