4.7 Article

Evaluating the influence of polymers on nucleation and growth in supersaturated solutions of acetaminophen

Journal

CRYSTENGCOMM
Volume 17, Issue 6, Pages 1242-1248

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ce02179g

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Funding

  1. National Science Foundation Engineering Research Center for Structured Organic Particulate Systems (NSF ERC-SOPS) [EEC-0540855]

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The nucleation behaviour of supersaturated acetaminophen was studied in the presence and absence of pharmaceutical polymers. Two different techniques involving turbidimetry and particle count analysis were used. Poly(vinylpyrrolidone) and the cellulosic polymers were found to be the most effective at nucleation inhibition at the supersaturation studied.

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