Journal
BIOENGINEERING-BASEL
Volume 7, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/bioengineering7040118
Keywords
skeletal muscle engineering; neuro-angiogenesis; growth factors; extracellular vesicles
Funding
- Swiss National Science Foundation [310030_172989]
- Progetto di Ateneo 2016 (Budget Integrato per la Ricerca dei Dipartimenti), Padova University
- Associazione Puzzle, Padova, Italy
- Swiss National Science Foundation (SNF) [310030_172989] Funding Source: Swiss National Science Foundation (SNF)
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Large-scale muscle injury in humans initiates a complex regeneration process, as not only the muscular, but also the vascular and neuro-muscular compartments have to be repaired. Conventional therapeutic strategies often fall short of reaching the desired functional outcome, due to the inherent complexity of natural skeletal muscle. Tissue engineering offers a promising alternative treatment strategy, aiming to achieve an engineered tissue close to natural tissue composition and function, able to induce long-term, functional regeneration after in vivo implantation. This review aims to summarize the latest approaches of tissue engineering skeletal muscle, with specific attention toward fabrication, neuro-angiogenesis, multicellularity and the biochemical cues that adjuvate the regeneration process.
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