Journal
TWIN RESEARCH AND HUMAN GENETICS
Volume 23, Issue 6, Pages 316-321Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/thg.2020.85
Keywords
SARS-CoV-2; COVID-19; heritability; twins; anosmia
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Funding
- Kennedy Trust
- Versus Arthritis
- Wellcome Trust
- Medical Research Council
- European Union
- Chronic Disease Research Foundation (CDRF)
- Zoe Global Ltd
- National Institute for Health Research (NIHR)-funded BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London
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Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n = 3261) completing the C-19 COVID-19 symptom tracker app allowed classical twin studies of COVID-19 symptoms, including predicted COVID-19, a symptom-based algorithm to predict true infection, derived from app users tested for SARS-CoV-2. We found heritability of 49% (32-64%) for delirium; 34% (20-47%) for diarrhea; 31% (8-52%) for fatigue; 19% (0-38%) for anosmia; 46% (31-60%) for skipped meals and 31% (11-48%) for predicted COVID-19. Heritability estimates were not affected by cohabiting or by social deprivation. The results suggest the importance of host genetics in the risk of clinical manifestations of COVID-19 and provide grounds for planning genome-wide association studies to establish specific genes involved in viral infectivity and the host immune response.
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