Journal
CHEMICAL SOCIETY REVIEWS
Volume 49, Issue 22, Pages 8137-8155Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cs00440e
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Funding
- University of Michigan's Life Sciences Institute, University of Michigan's Department of Chemistry
- National Institutes of Health [R35 GM124880]
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Catalytic C-H oxyfunctionalization reactions have garnered significant attention in recent years with their ability to streamline synthetic routes toward complex molecules. Consequently, there have been significant strides in the design and development of catalysts that enable diversification through C-H functionalization reactions. Enzymatic C-H oxygenation reactions are often complementary to small molecule based synthetic approaches, providing a powerful tool when deployable on preparative-scale. This review highlights key advances in scalable biocatalytic C-H oxyfunctionalization reactions developed within the past decade.
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