Journal
JOURNAL OF VETERINARY MEDICAL SCIENCE
Volume 82, Issue 7, Pages 978-982Publisher
JAPAN SOC VET SCI
DOI: 10.1292/jvms.20-0140
Keywords
BDE-209; cat; chronic exposure; cytochrome P450; mRNA expression
Categories
Funding
- Japan Society for the Promotion of Science [16H02989, 17K20038, 16H01779]
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan
- Grants-in-Aid for Scientific Research [17K20038, 16H02989] Funding Source: KAKEN
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The knowledge of cytochrome P450 (CYP) expression involved in chemical exposure are necessary in clinical applications for the medication and prediction of adverse effects. The aim of this study was to evaluate the mRNA expression of CYP1-CYP3 families in cats exposed to BDE-209 for one year. All selected CYP isoforms showed no significant difference in mRNA expressions between control and exposure groups, however, CYP3A12 and CYP3A131 revealed tend to be two times higher in the exposure group compared to control group. The present results indicate that the chronic exposure of BDE209 could not alter CYP expression in the liver of cats. This result considered caused by the deficiency of CYP2B subfamily which is major metabolism enzyme of polybrominated diphenyl ethers ( PBDEs) in cat.
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