Journal
PHARMACEUTICAL BIOLOGY
Volume 58, Issue 1, Pages 1131-1139Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13880209.2020.1844761
Keywords
Rheumatoid arthritis; anaemia of inflammation; natural products of ginsenosides
Funding
- National Nature Science Foundation of China [81503084]
- Anhui University Natural Science Research Project [KJ2019A0263]
Ask authors/readers for more resources
Context Ginsenoside compound K (CK) has anti-inflammatory, immunoregulatory, and myelosuppressive protective effects. Methotrexate (MTX) is widely used in combination therapy for rheumatoid arthritis (RA). Objective To evaluate the effects of combination therapy of CK and MTX on anaemia and anti-arthritis in adjuvant-induced arthritis (AA) rats. Materials and methods AA was induced in rats by Complete Freund's adjuvant, and divided into five groups (n = 10): normal, AA, CK 80 mg/kg, combination therapy (80 mg/kg CK combined with 0.5 mg/kg MTX), and MTX 0.5 mg/kg. From day 12, CK (once a day for 15 days) or MTX (once every 3 days, five times) were intragastrically administered. Results Combination therapy showed increased haemoglobin to 148.5 +/- 10.1 g/L compared with AA (129.8 +/- 11.7 g/L) and MTX (128.8 +/- 18.4 g/L), and decreased reticulocytes in peripheral blood to 4.9 +/- 1.1% compared with MTX (9.3 +/- 3.3%). In combination therapy group, paw swelling decreased to 5.6 +/- 4.3 mL compared with CK (9.4 +/- 3.9 mL) and MTX (13.5 +/- 7.4 mL), and swollen joint count decreased to 1.4 +/- 0.8 compared with CK (2.1 +/- 1.0) and MTX (2.4 +/- 1.2) at day 24. Combination therapy showed decreased IL-6 to 25.1 +/- 17.2 pg/mL compared with MTX (44.9 +/- 4.8 pg/mL), and decreased IL-17 to 5.8 +/- 3.9 pg/mL compared with MTX (10.7 +/- 4.2 pg/mL). Conclusion The anti-anaemia effect of CK deserves further study, and CK can be a candidate effective drug for combined treatment in RA with anaemia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available