Journal
NANOTECHNOLOGY REVIEWS
Volume 9, Issue 1, Pages 1059-1079Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/ntrev-2020-0084
Keywords
bioactive component; hyaluronic acid; bone regeneration; 3D printing; tissue engineering
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Funding
- National Key Research and Development Program of China [2018YFC1106800, 2018YFB1105600]
- National Natural Science Foundation of China [31971251, 31870961]
- Sichuan Province Science & Technology Department Projects [2019YFH0079, 2016CZYD0004, 2019JDTD0008, 2020YFS0036, 2020YFS0462]
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Hyaluronic acid (HA) is widely distributed in the human body, and it is heavily involved in many physiological functions such as tissue hydration, wound repair, and cell migration. In recent years, HA and its derivatives have been widely used as advanced bioactive polymers for bone regeneration. Many medical products containing HA have been developed because this natural polymer has been proven to be nontoxic, noninflammatory, biodegradable, and biocompatible. Moreover, HA-based composite scaffolds have shown good potential for promoting osteogenesis and mineralization. Recently, many HA-based biomaterials have been fabricated for bone regeneration by combining with electrospinning and 3D printing technology. In this review, the polymer structures, processing, properties, and applications in bone tissue engineering are summarized. The challenges and prospects of HA polymers are also discussed.
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