Mechanochemical Cross-Coupling Reactions

In recent years, solvent-less mechanochemical organic transformations using ball milling have come to the forefront of organic synthesis as cleaner and sustainable synthetic alternatives. Apart from the environmental benefits, mechanochemical approaches potentially enable access to novel chemical space that has reactivities and selectivities different from those of conventional solution-based reactions. In this review, we highlight important recent contributions to cross coupling chemistry using ball milling, with particular emphasis on new synthetic strategies and concepts based on mechanochemical reaction environments that enable the rapid and selective construction of complex molecules.