Journal
GENES & DISEASES
Volume 7, Issue 4, Pages 520-527Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.gendis.2020.06.009
Keywords
Acute respiratory distress syndrome; COVID-19; Cytokine storm; Hyper-inflammatory host response; SARS-CoV-2
Funding
- National Natural Science Foundation of China [81801894, 81873928]
- High-level Medical Reserved Personnel Training Project of Chongqing
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Coronavirus Disease 2019 (COVID-19) was first identified in China at the end of 2019. Acute respiratory distress syndrome (ARDS) represents the most common and serious complication of COVID-19. Cytokine storms are a pathophysiological feature of COVID-19 and play an important role in distinguishing hyper-inflammatory subphenotypes of ARDS. Accordingly, in this review, we focus on hyper-inflammatory host responses in ARDS that play a critical role in the differentiated development of COVID-19. Furthermore, we discuss inflammation-related indicators that have the potential to identify hyper-inflammatory subphenotypes of COVID-19, especially for those with a high risk of ARDS. Finally, we explore the possibility of improving the quality of monitoring and treatment of COVID-19 patients and in reducing the incidence of critical illness and mortality via better distinguishing hyperand hypo inflammatory subphenotypes of COVID-19. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.
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