4.4 Review

Arming the troops: Post-translational modification of extracellular bacterial proteins

Journal

SCIENCE PROGRESS
Volume 103, Issue 4, Pages -

Publisher

SAGE PUBLICATIONS LTD
DOI: 10.1177/0036850420964317

Keywords

Post-translational modification; protein secretion; bacterial pathogens; bacterial virulence factors; proteomics; methylation; acetylation; glycosylation; lipidation

Funding

  1. BBSRC DTP
  2. Evelyn Trust (Cambridge)
  3. Cystic Fibrosis Trust
  4. British Lung Foundation
  5. BBSRC

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Protein secretion is almost universally employed by bacteria. Some proteins are retained on the cell surface, whereas others are released into the extracellular milieu, often playing a key role in virulence. In this review, we discuss the diverse types and potential functions of post-translational modifications (PTMs) occurring to extracellular bacterial proteins.

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