Journal
INFECTION AND DRUG RESISTANCE
Volume 13, Issue -, Pages 4115-4123Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S268744
Keywords
risk factors; mortality; Pseudomonas aeruginosa; bacteremia
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Funding
- National Science Fund for Distinguished Young Scholars [81425001/H0104]
- CAMS Innovation Fund for Medical Sciences [CIFMS 2018-I2M-1-003]
- National Key Research and Development Program of China [2018YFC1200102]
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Purpose: Pseudomonas aeruginosa bacteremia presents a severe challenge to hospitalized patients. However, to date, the risk factors for mortality among inpatients with P. aeruginosa bacteremia in China remain unclear. Patients and Methods: This retrospective multicenter study was performed to analyze 215 patients with culture-confirmed P. aeruginosa bacteremia in five healthcare centers in China during the years 2012-2019. Results: Of 215 patients with P. aeruginosa bacteremia, 61 (28.4%) died during the study period. Logistic multivariable analysis revealed that cardiovascular disease (OR=3.978, P=0.001), blood transfusion (OR=5.855, P<0.001) and carbapenem-resistant P. aeruginosa (CRPA) phenotype (OR=4.485, P=0.038) constituted the independent risk factors of mortality. Furthermore, both CRPA and multidrug-resistant P. aeruginosa (MDRPA) phenotypes were found to be significantly associated with 5-day mortality (Log-rank, P<0.05). Conclusion: This study revealed a high mortality rate amongst hospitalized patients with P. aeruginosa bacteremia, and those with cardiovascular diseases, CRPA and MDRPA phenotypes, should be highlighted and given appropriate management in China.
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