Journal
CELL REPORTS
Volume 33, Issue 6, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2020.108368
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Funding
- DBT-Wellcome Trust India Alliance [IA/M/16/1/502606]
- Wellcome Trust-DBT India Alliance [IA/E/15/1/502342]
- DBT-IISc Partnership Program Phase II [BT/PR27952/INF/22/212/2018/21.01.2019]
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Tissue injury is one of the most severe environmental perturbations for a living organism. When damage occurs in adult Drosophila, there is a local response of the injured tissue and a coordinated action across different tissues to help the organism overcome the deleterious effect of an injury. We show a change in the transcriptome of hemocytes at the site of tissue injury, with pronounced activation of the Toll signaling pathway. We find that induction of the cytokine upd-3 and Toll receptor activation occur in response to injury alone, in the absence of a pathogen. Intracellular accumulation of hydrogen peroxide in hemocytes is essential for upd-3 induction and is facilitated by the diffusion of hydrogen peroxide through a channel protein Prip. Importantly, hemocyte activation and production of reactive oxygen species (ROS) at the site of a sterile injury provide protection to flies on subsequent infection, demonstrating training of the innate immune system.
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