Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 45, Pages 28452-28462Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2000759117
Keywords
orbitofrontal cortex; reward; functional connectivity; lateralization
Categories
Funding
- McDonnell Center for Systems Neuroscience at Washington University
- Wellcome Trust [203139/Z/16/Z, WT100973AIA, 103184/Z/13/Z, 202831/Z/16/Z, 105238/Z/14/Z]
- Medical Research Council [MR/T023007/1, MR/P024955/1, G0902373]
- Bettencourt Schueller Foundation
- Christ Church, University of Oxford
- [1U54MH091657]
- MRC [MR/P024955/1, G0902373] Funding Source: UKRI
- UKRI [MR/T023007/1] Funding Source: UKRI
- Wellcome Trust [202831/Z/16/Z, 103184/Z/13/Z, 105238/Z/14/Z] Funding Source: Wellcome Trust
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The orbitofrontal cortex (OFC) is a key brain region involved in complex cognitive functions such as reward processing and decision making. Neuroimaging studies have reported unilateral OFC response to reward-related variables; however, those studies rarely discussed this observation. Nevertheless, some lesion studies suggest that the left and right OFC contribute differently to cognitive processes. We hypothesized that the OFC asymmetrical response to reward could reflect underlying hemispherical difference in OFC functional connectivity. Using resting-state and reward-related functional MRI data from humans and from rhesus macaques, we first identified an asymmetrical response of the lateral OFC to reward in both species. Crucially, the subregion show ing the highest reward-related asymmetry (RRA) overlapped with the region showing the highest functional connectivity asymmetry (FCA). Furthermore, the two types of asymmetries were found to be significantly correlated across individuals. In both species, the right lateral OFC was more connected to the default mode network compared to the left lateral OFC. Altogether, our results suggest a functional specialization of the left and right lateral OFC in primates.
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