Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 88, Pages 13583-13586Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc06054b
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Funding
- National Natural Science Foundation of China [21705082, 91743107]
- Natural Science Foundation of Jiangsu Province in China [BK20170444]
- State Key Laboratory of Analytical Chemistry for Life Science [SKLACLS2013]
- Science and Technology Plan Projects of Nantong [XG202008-4]
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A DNA framework assembled split G4 nanodevice was fabricated to realize microRNA imaging in living HeLa cells. After hybridization with the target, the separated G4 segments underwent structural transformations, which could initiate fluorescence resonance energy transfer (FRET) processes. Our design may pave a novel way to facilitate applications of the G4 motif.
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