Journal
CRYSTENGCOMM
Volume 17, Issue 11, Pages 2346-2352Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ce00036j
Keywords
-
Categories
Funding
- National Centre for Research and Development, Poland [INNOTECH-K2/IN2/65/182982/NCBR/13]
- European Regional Development Found in the Sectoral Operational Programme Improvement of the Competitiveness of Enterprises [WKP_1/1.4.3./1/2004/72/72/165/2005/U]
Ask authors/readers for more resources
Three crystalline forms of dutasteride, known in the literature as forms I, II and III, were studied. It has been proved that only form I is an unsolvated form. Both forms II and III are hydrates (pseudopolymorphs). Phase transition studies performed by thermoanalytical techniques and variable temperature PXRD measurements, in the temperature region from 30 to 180 degrees C, revealed that dehydration leads to an unstable phase, which finally transforms into form I. Details of the crystal and molecular structure of form I are presented. Dutasteride form I crystallizes in the orthorhombic P2(1)2(1)2(1) space group with one molecule in the asymmetric part of the unit cell. Dutasteride molecules form a herringbone bond-like pattern with pairs of neighboring 'heads' of lactam groups.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available