Greener and Environmentally Benign Methodology for the Synthesis of Pyrazole Derivatives

Pyrazole and its derivatives are one of the interesting heterocyclic compounds among the other because it has tremendous important bio-medical applications such as anticancer, antimalarial, antimicrobial, antifungal, antitubercular and antihelishmanial. Synthesis of pyrazoles by synthetic route requires harsh reaction conditions such as organic solvent, high temperature, require large time that consume more energy which increase final cost of the synthesis of pyrazoles. Therefore researchers be aware about synthesis and give more attention towards to develop a greener as well as economically favorable method for synthesis of pyrazoles such as microwave irradiation, ultra-sonication assisted, reaction at room temperature, solvent and catalyst free and use of universal solvent that is aqueous medium these techniques are environmentally friendly as well as cost effective. Therefore, these review highlights the greener methodologies for the synthesis of pyrazoles, which are good alternative for synthetic methods that sustains green principles.