Journal
CHEMICAL SCIENCE
Volume 11, Issue 42, Pages 11548-11553Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc03883k
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Funding
- National Natural Science Foundation of China [21871147, 91956106, 21602114]
- Fundamental Research Funds for Central Universities [2122018165]
- Tencent Foundation
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Herein, we report unprecedented aluminum-catalyzed halodefluorination reactions of trifluoromethyl- and difluoroalkyl-substituted olefins with bromo- or chlorotrimethylsilane. The interesting feature of these reactions is that one, two, or three fluorine atoms can be selectively replaced with bromine or chlorine atoms by modification of the reaction conditions. The generated products can undergo a variety of subsequent transformations, thus constituting a valuable stock of building blocks for installing fluorine-containing olefin motifs in other molecules.
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