Journal
CLINICAL & TRANSLATIONAL IMMUNOLOGY
Volume 9, Issue 10, Pages -Publisher
WILEY
DOI: 10.1002/cti2.1186
Keywords
Gasdermins; inflammatory bowel disease; multiple sclerosis; NETosis; pyroptosis; rheumatoid arthritis
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Funding
- Innovative and Enhancement Research Program of Guangdong Province [2019KTSCX025]
- Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine [YN2018QJ03]
- Natural Science Foundation of Guangdong Province [2017A030313639]
- Medical Scientific Research Foundation of Guangdong Province [A2017277]
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The gasdermins, family of pore-forming proteins, are emerging key regulators of infection, autoinflammation and antitumor immunity. Multiple studies have recently characterised their crucial roles in driving pyroptosis, a lytic pro-inflammatory type of cell death. Additionally, gasdermins also act as key effectors of NETosis, secondary necrosis and apoptosis. In this review, we will address current understanding of the mechanisms of gasdermin activation and further describe the protective and detrimental roles of gasdermins in host defence and autoinflammatory diseases. These data suggest that gasdermins play a prominent role in innate immunity and autoinflammatory disorders, thereby providing potential new therapeutic avenues for the treatment of infection and autoimmune disease.
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