Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 45, Pages 9275-9283Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01373k
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Funding
- Junta de Castilla y Leon [FEDER-VA115P17, VA149G18]
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Two novel polymers of intrinsic microporosity decorated with chiral thioureas have been used as recoverable organocatalysts in enantioselective alpha-amination of 3-aryl-substituted oxindoles, creating a quaternary stereocenter. Both catalysts were able to promote the reaction in excellent yields and good enantioselection. Catalyst II, with a pyridyl nucleus, was used in recycling experiments maintaining the activity without additional reactivation, and in flow processes allowing the synthesis of the amination product in multigram scale.
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