Journal
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
Volume 23, Issue 6, Pages 511-520Publisher
KOREAN SOC PEDIATRIC GASTROENTEROLOGY & NUTRITION
DOI: 10.5223/pghn.2020.23.6.511
Keywords
Locust bean gum; Quality of life; Gastro-esophageal reflux; Infant formula; Defecation; Diarrhea; Crying
Categories
Funding
- Laboratoires Gallia, Limonest, France
- Nutricia, the Netherlands
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Purpose: Thickened infant formulas reduce regurgitation frequency and volume. Because the digestive tolerance of locust bean gum-containing formulas is controversial, the effectiveness and tolerance of a locust bean gum-thickened formula in infants presenting with regurgitation was evaluated. No other interventions were allowed during the 1 month follow-up period. Methods: We conducted an open, prospective, observational study of a locust bean gum-thickened formula administered to infants presenting with moderate to severe regurgitation according to parents during 1 month. Effectiveness and tolerance were assessed by evaluating gastrointestinal symptoms and quality of life indicators. Results: A total of 2,604 infants with an average age of 9.3 +/- 4.3 weeks were included in this 1 month trial. Regurgitation frequency and estimated volume decreased significantly (p < 0.001) and the episodes were resolved completely in 48% of the infants. A significant decrease in duration of crying and episodes of gas (p < 0.001), with improvement in quality of life parameters, was observed. Stool frequency increased and stool consistency softened (p < 0.001) to levels within the physiologic range, consistent with the increased fiber load (0.42 g/100 mL). Conclusion: Locust bean gum-thickened formula decreased infant regurgitation, was well tolerated, and improved parental quality of life. Stool composition and frequency of the infants remained within the physiologic range.
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