Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 92, Pages 14499-14502Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc05466f
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Funding
- EPSRC
- BBSRC [PR140003]
- University of Warwick
- Birmingham Science City Advanced Materials Project 1 - Advantage West Midlands (AWM)
- Birmingham Science City Advanced Materials Project 2 - Advantage West Midlands (AWM)
- European Regional Development Fund (ERDF)
- Engineering and Physical Sciences Research Council (EPSRC) Centre for Doctoral Training Studentship from the Institute of Chemical Biology (Imperial College London)
- AstraZeneca
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Cholesterol is a crucial component of biological membranes and can interact with other membrane components through hydrogen bonding. NMR spectroscopy has been used previously to investigate this bonding, however this study represents the first O-17 NMR spectroscopy study of isotopically enriched cholesterol. We demonstrate the O-17 chemical shift is dependent on hydrogen bonding, providing a novel method for the study of cholesterol in bilayers.
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